Publications
    • Pan L, Yang J, Yang Q, Wang X, Zhu L, Liu Y, Lou H, Xu C, Shen Y, Wang H. A critical period for the rapid modification of synaptic properties at the VPm relay synapse. Front Mol Neurosci 2017 Jul 25;10:238. doi: 10.3389/fnmol.2017.00238.

    • Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y, Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chang Q, Pang ZP, Huganir RL, Zhu JJ. BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method. Genes Dev. 2017 Mar 15; 31(6):537-552.

    • Yang J, Cheng X, Shen J, Xie B, Zhao X, Zhang Z, Cao Q, Shen Y, Qiu M. A novel approach for amplification and purification of mouse oligodendrocyte progenitor cells. Front Cell Neurosci. 2016 Aug 22; 10:203. doi: 10.3389/fncel.2016.00203.

    • Li YH, Zhang N, Wang YN, Shen Y, Wang Y. Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. Neurochemistry International. 2016 Sep;98:115-21. doi: 10.1016/j.neuint.2016.03.001.

    • Zhou L, Yang D, Wang DJ, Xie YJ, Zhou JH, Zhou L, Huang H, Han S, Shao CY, Li HS, Zhu JJ, Qiu MS, De Zeeuw CI, Shen Y. Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15474-9

    • Li Y, Li F, Bai B, Wu Z, Hou X, Shen Y, Wang Y. Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells. Mol Med Rep. 2017 Jul 21. doi: 10.3892/mmr.2017.7056.

    • Cao LH, Jing BY, Yang D, Zeng X, Shen Y, Tu Y, Luo DG. Distinct signaling of drosophila chemoreceptors in olfactory sensory neurons. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E902-11. doi: 10.1073/pnas.1518329113.

    • Wang YN, Zhou L, Li YH, Wang Z, Li YC, Zhang YW, Wang Y, Liu G, Shen Y. Protein interacting with C-kinase 1 deficiency impairs glutathione synthesis and increases oxidative stress via reduction of surface excitatory amino acid carrier 1. Journal of Neuroscience. 22 April 2015, 35(16):6429-6443.

    • Zhou L*, Shao CY*, Xu SM, Xie YJ, Zhou L, Teng P, Wang Y, Qiu M, Shen Y. GSK3β promotes the differentiation of oligodendrocyte precursor cells via β-catenin-mediated transcriptional regulation. Molecular Neurobiology. 2014. *Co-first authors.

    • Wang DJ, Su LD, Wang YN, Yang D, Sun CL, Zhou L, Wang XX, Shen Y. Long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses requires pre- and postsynaptic signaling cascades. Journal of Neuroscience. 2014 Feb 5; 34(6):2355-2364.

    • Xie YJ*, Zhou L*, Jiang N, Zhang N, Zou N, Zhou L, Wang Y, Cowell JK, Shen Y. Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum. Scientific Reports. 2015 Jan (5) : 7827 .*Co-first authors.

    • Ji YF*, Zhou L*, Xie YJ*, Xu SM, Zhu J, Teng P, Shao CY, Wang Y, Luo JH, Shen Y*. Up-regulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кBcascade in astrocytic oxygen-glucose deprivation. Glia. 2013 Dec 61(12)::1959-75. * Co-first authors.

    • Cheng W, Li Y, Hou X, Bai B, Li F, Ding F, Ma J, Zhang N, Shen Y, Wang Y. Determining the neuroprotective effects of dextromethorphan in lipopolysaccharide‑stimulated BV2 microglia. Molecular Medicine Report. 2015 Feb;11(2):1132-8.

    • Zhu J, Wang Z, Zhang N, Ma J, Xu SL, Wang Y, Shen Y, Li YH. Protein interacting C-kinase 1 modulates surface expression of P2Y6 purinoreceptor, actin polymerization and phagocytosis in microglia. Neurochemical Research. 2016 Apr;41(4):795-803. doi: 10.1007/s11064-015-1754-3.

    • Jiang NW*, Wang DJ*, Xie YJ*, Zhou L, Su LD, Li H, Wang QW, Shen Y. Downregulation of glutamate transporter EAAT4 by conditional knockout of Rheb1 in cerebellar Purkinje cells. Cerebellum. 2015 Jul 21. doi: 10.1007/s12311-015-0701-9. *Co-first authors.

    • Li QJ, Wang Z, Yao YX, Jin SH, Qian MZ, Li NN, Wang YN, Zhang YW, Chen BY, Jia DY, Shen Y*, Wang JL*. Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw. Neurochemical Research. 2015 Mar; 40(3):579-590.

    • Su LD*, Xie YJ*, Zhou L, Shen Y, Hu YH. LGI1 is involved in the development of mouse brain. Cerebellum. 2015 Feb;14(1):12-14. doi: 10.1007/s12311-014-0628-6. *co-first authors.

    • Wang G, Wyskiel DR, Yang W, Wang Y, Milbern LC, Lalanne T, Jiang X, Shen Y, Sun QQ, Zhu JJ. An optogenetics- and imaging-assisted simultaneous multiple patch-clamp recordings system for decoding complex neural circuits. Nature protocols. 2015. 10:397-412.

    • Lee AJ, Wang G, Jiang X, Johnson SM, Hoang ET, Lanté F, Stornetta RL, Beenhakker MP, Shen Y, Zhu JJ. Canonical organization of layer 1 neuron-led cortical inhibitory and disinhibitory interneuronal circuits. Cerebral Cortex. 2014 Feb 18. doi: 10.1093/cercor/bhu020./"PDF

    • Cheng W, Li Y, Hou X, Zhang N, Ma J, Ding F, Li F, Miao Z, Zhang Y, Qi Q, Li G, Shen Y, Liu J, Huang W, Wang Y. HSP60 is involved in the neuroprotective effects of naloxone. 2014; Molecular Medicine Reports. 10:2172-2176.

    • Wang Z*, Wang YN*, Sun CL*, Yang D, Su LD, Xie YJ, Zhou L, Wang Y, Shen Y. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCα complex and cerebellar plasticity. PLoS One. 2013 Dec 16; 8(12):e83862. *co-first authors./"PDF/"

    • Shen Y. Retrospect and inspiration from 5th international symposium, society for research on the cerebellum. Cerebellum. 2013 Jun; 12(3):291-293./"PDF

    • Shao CY*, Zhu J*, Xie YJ, Wang Z, Wang YN, Wang Y, Su LD, Zhou L, Zhou TH, Shen Y. Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport. Traffic. 2013 Jul;14(7):785-797. * Co-first authors.

    • Sun T, Yu N, Zhai LK, Li N, Zhang C, Zhou L, Huang Z, Jiang XY, Shen Y, Chen ZY. c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin and JNK-dependent manner. Journal of Biological Chemistry. 2013 May 17;288(20):14531-14543. doi: 10.1074/jbc.M113.464453.

    • Zou N*, Wu X*, Jin YY, He MZ, Wang XX, Su LD, Rupnik M, Liang L, Wu ZY, Shen Y. ATP regulates sodium channel kinetics in pancreatic islet beta-cells. Journal of Membrane Biology. 2013 Feb;246(2):101-107./"PDF

    • Li Q, Zhou L,Shen Y. Recent research progresses of transferrin receptor 1 in central nervous system. Sheng Li Ke Xue Jin Zhan. 2012 Jun; 43(3):188-92. Chinese.

    • Su LD*, Wang DJ*, Yang D, Shen Y, Hu YH. Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. Cerebellum. 2013. Jun;12(3):297-9. doi: 10.1007/s12311-012-0444-9. *Co-first authors.

    • Zhu J*, Shao CY*, Yang W, Zhang XM, Wu ZY, Zhou L, Wang XX, Li YH, Xia J, Luo JH, Shen Y Chronic zinc exposure decreases the surface expression of NR2A-containing NMDA receptors in cultured hippocampal neurons. PLoS One. 2012;7(9):e46012. doi: 10.1371/journal.pone.0046012. Epub 2012 Sep 25.

    • Wang DJ*, Yang D*, Su LD*, Xie YJ, Zhou L, Sun CL, Wang Y, Wang XX, Zhou L, Shen Y. Cytosolic Phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum. PLoS One. 2012;7(8):e41499. doi: 10.1371/journal.pone.0041499. Epub 2012 Aug 22. Erratum in: PLoS One. 2012;7(11). doi:10.1371/annotation/d08032c8-4a27-4c9c-8ef7-b3ec64351cde.

    • Wu ZY, Zhu LJ, Zou N, Bombek LK, Shao CY, Wang N, Wang XX, Liang L, Xia J, Rupnik M, Shen Y. AMPA receptors regulate exocytosis and insulin release in pancreatic β cells. Traffic. 2012 Aug;13(8):1124-1139.

    • Sun CL, Su LD, Li Q, Wang XX, Shen Y. Cerebellar long-term depression is deficient in Niemann–Pick type C disease mice. Cerebellum. 2011 Mar;10(1):88-95.

    • Zou J*, Zhou L*, Du XX*, Ji YF*, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B. Rheb1 is required for mTORC1 and myelination in postnatal brain development. Development Cell. 2011 Jan 18. 20 (1):97-108.*Co-first authors.

    • Wu ZY, Zou N, Shen Y. Glutamate receptors and gamma-aminobutyric acid receptors in pancreatic cells. Sheng Li Ke Xue Jin Zhan. 2011 Aug; 42(4):256-60. Review. Chinese.

    • Su LD, Sun CL, Shen Y. Ethanol acutely modulates mGluR1-dependent long-term depression in cerebellum. Alcoholism: Clinical and Experimental Research. 2010 Jul;34(7):1140-1145.

    • Shao X, Zhu L, Wang Y, Lu Y, Wang W, Zhu J, Shen Y, Xia J, Luo J. Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization. Neurochemistry International. 2010; 56(8):962-970.

    • Ji YF, Xu SM, Zhu J, Wang XX, Shen Y. Insulin increases glutamate transporter GLT1 in cultured astrocytes. Biochemical and Biophysical Research Communications. 2011 Feb 25;405(4):691-6.

    • Su LD, Shen Y. Blockade of glutamate transporters facilitates cerebellar synaptic long-term depression. NeuroReport.2009 Mar 25;20(5):502-507. /"PDF

    • Shen Y, Linden DJ. Long-term potentiation of neuronal glutamate transporter. Neuron 2005. 46(5):715-722. JUN 2 2005.

    • Steinberg JP, Takamiya K, Shen Y, Xia J, Rubio ME, Yu S, Jin W, Thomas GM, Linden DJ, Huganir RL Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron. 2006 Mar 16; 16;49(6):845-860.

    • Ramanan N, Shen Y, Sarsfield SL, Linden DJ and Ginty DD. Distinct requirements for SRF and CREB in neuronal survival and synaptic plasticity. Nature Neuroscience 2005 Jun; 8(6):759-767.

    • Shen Y, Lu T, Yang XL. Modulation of desensitization at glutamate receptors in isolated crucian carp horizontal cells by concanavalin A, cyclothiazide, aniracetam and PEPA. Neuroscience. 1999 Mar; 89(3):979-990.

    • Shen Y, Yang XL. Zinc modulation of AMPA receptors may be relevant to splice variants in carp retina. Neuroscience Letters. 1999 Jan 15; 259(3):177-180.

    • Shen Y, Zhou Y, Yang XL.Characterization of AMPA receptors on isolated amacrine-like cells in carp retina. European Journal of Neuroscience. 1999 Dec; 11(12):4233-4240.

    • Shen Y, Hansel C, Linden DJ. Glutamate release during LTD at cerebellar climbing fiber-Purkinje cell synapses. Nature Neuroscience. 2002 Aug; 5(8):725-726.

    • Shen Y, Kishimoto K, Linden DJ, Sapirstein A Cytosolic phospholipase A(2) alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment. Proceedings of National Academy of Science USA. 2007; 104(14):6078-6083.

    • Lu T, Shen Y, Yang XL.Desensitization of AMPA receptors on horizontal cells isolated from crucian carp retina. Neuroscience Research. 1998 Jun; 31(2):123-135.