王晓东博士，浙江大学脑科学与脑医学学院教授、博士生导师。2011年4月博士毕业于德国马克斯•普朗克精神病学研究所/慕尼黑大学生物学专业；2011年5月至2012年11月于德国马克斯•普朗克精神病学研究所继续从事博士后研究；2013年1月至2013年10月于北京大学第六医院开展研究工作，任助理研究员、副研究员；2013年11月加盟浙江大学医学院。

王晓东博士运用行为学、药理学、形态学与分子生物学方法，在应激所致认知损害及神经元结构发育与可塑性障碍的分子机制方面开展了一系列工作，相关研究被 Nature Reviews Drug Discovery、、Nature Neuroscience、Trends in Neuroscience和Faculty of 1000等评述并被国际同行多次引用。研究课题获得国际脑研究组织归国基金、国家自然科学基金青年基金及面上项目等资助。

实验室主页：https://person.zju.edu.cn/neurostress

代表性论文：

Wang C^#, Liu H^#, Li K^#, Wu ZZ, Wu C, Yu JY, Gong Q, Fang P, Wang XX, Duan SM, Wang H, Gu Y, Hu J, Pan BX, Schmidt MV, Liu YJ, Wang XD* (2020). Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis. Nature Communications 11, 6045.

Liu YJ*, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS*, Wang XD*, Duan S* (2020). Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD.Science Advances 6, eaba5783.

Yu JY, Fang P, Wang C, Wang XX, Li K, Gong Q, Luo BY, Wang XD* (2018). Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits. Neuropharmacology 135, 474-486.

Gong Q, Su YA, Wu C, Si TM, Deussing JM, Schmidt MV, Wang XD* (2018). Chronic stress reduces nectin-1 mRNA levels and disrupts dendritic spine plasticity in the adult mouse perirhinal cortex. Frontiers in Cellular Neuroscience 12, 67.

Li K^#, Shen S^#, Ji YT, Li XY, Zhang LS, Wang XD* (2018). Melatonin augments the effects of fluoxetine on depression-like behavior and hippocampal BDNF-TrkB signaling. Neuroscience Bulletin 34, 303-311.

Li JT^#, Xie XM^#, Yu JY, Sun YX, Liao XM, Wang XX, Su YA, Liu YJ, Schmidt MV, Wang XD*, Si TM* (2017). Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss. Cell Reports 21, 891-900.

Wang XX, Li JT, Xie XM, Gu Y, Si TM, Schmidt MV, Wang XD* (2017) Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory. Translational Psychiatry 7, e1228.

Yang XD, Liao XM, Uribe-Marino A, Liu R, Xie XM, Jia J, Su YA, Li JT, Schmidt MV, Wang XD*, Si TM* (2015). Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1. Neuropsychopharmacology 40, 1203-1215.

Liao XM, Yang XD, Jia J, Li JT, Xie XM, Su YA, Schmidt MV, Si TM*, Wang XD* (2014). Blockade of corticotropin-releasing hormone receptor 1 attenuates early-life stress-induced synaptic abnormalities in the neonatal hippocampus. Hippocampus 25, 528-540.

Wang XD, Su YA, Avrabos C, Wagner KV, Liebl C, Wolf M, Scharf SH, Hartmann J, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV* (2013). Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nature Neuroscience 16, 706-713.

Wang XD*, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV (2011). Forebrain CRF1 modulates early life stress-programmed cognitive deficits. The Journal of Neuroscience 31, 13625-13634.

Wang XD*, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV (2011). Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiology of Disease 42, 300-310.