My primary research interests are the neuronal mechanism mediating the maintenance of chronic pain.  Chronic pain is one of important human disease which affects about 18% people in our society.  The major pathological phenomena of chronic pain include mechanical allodynia, hypergesia and spontaneous pain, except that, the suffering of chronic pain also lead patients to depression, anxiety, loss of working ability.  Drug treatment is the major way for chronic pain managements.  However, only about 40-50% of patients get partially pain release with some kind of side effects.  Therefore the neuronal mechanism mediating chronic pain need to be further studied.  We will focus on the molecular mechanism for the abnormal energy metabolism under chronic pain condition, and the neuronal circuits and information coding mechanism for chronic pain.