Liao RJ, Jiang L, Wang RR, Zhao HW, Chen Y, Li Y, Wang L, Jie LY, Zhou YD, Zhang XN, Chen Z, Hu WW. Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration.Sci Rep. 2015 Oct 20;5:15356.

Zhou Y, Zhang J, Wang L, Chen Y, Wan Y, He Y, Jiang L, Ma J, Liao R, Zhang X, Shi L, Qin Z, Zhou Y, Chen Z, Hu W. Interleukin-1β impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion. Brain Behav Immun. 2016 Sep 20. pii: S0889-1591(16)30433-0.

Chen B, Feng B, Tang Y, You Y, Wang Y, Hou W, Hu W, Chen Z. Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window. Exp Neurol. 2016 Sep;283(Pt A):29-38.

Feng B, Tang Y, Chen B, Xu C, Wang Y, Dai Y, Wu D, Zhu J, Wang S, Zhou Y, Shi L, Hu W, Zhang X, Chen Z. Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling. Sci Rep. 2016 Feb 23;6:21931.

Xu ZH, Wang Y, Tao AF, Yu J, Wang XY, Zu YY, Zhang SH, Chen Z. Interleukin-1 receptor is a target for adjunctive control of diazepam-refractory status epilepticus in mice. Neuroscience. 2016 Jul 22;328:22-9.

Wang Y, Ying X, Chen L, Liu Y, Wang Y, Liang J, Xu C, Guo Y, Wang S, Hu W, Du Y, Chen Z. Electroresponsive Nanoparticles Improve Antiseizure Effect of Phenytoin in Generalized Tonic-Clonic Seizures. Neurotherapeutics. 2016 Jul;13(3):603-13.

Xu C, Wang S, Wang Y, Lin K, Pan G, Xu Z, Gonzalez-Martinez J, Gao F, Wu X, Zhang S, Bulacio JC, Najm IM, Luo J, Hu W, Wu Z, So NK, Chen Z. A decrease of ripples precedes seizure onset in mesial temporal lobe epilepsy. Exp Neurol. 2016 Oct;284(Pt A):29-37.

Yu J, Tang YY, Wang RR, Lou GD, Hu TT, Hou WW, Yue JX, Ohtsu H, Shi LY, Zhang SH, Chen Z. A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain. J Neuroinflammation. 2016 Jun 24;13(1):163.

Shen Z, Jiang L, Yuan Y, Deng T, Zheng YR, Zhao YY, Li WL, Wu JY, Gao JQ, Hu WW, Zhang XN, Chen Z. Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury. CNS Neurosci Ther. 2015 Mar;21(3):271-9

Zhao YY, Yuan Y, Chen Y, Jiang L, Liao RJ, Wang L, Zhang XN, Ohtsu H, Hu WW, Chen Z. Histamine promotes locomotion recovery after spinal cord hemisection via inhibiting astrocytic scar formation.CNS Neurosci Ther. 2015 May;21(5):454-62.

Tao AF, Xu ZH, Chen B, Wang Y, Wu XH, Zhang J, Tang YS, Xu CL, Zhao HW, Hu WW, Shi LY, Zhang SH, Chen Z. The Pro-inflammatory Cytokine Interleukin-1β is a Key Regulatory Factor for the Postictal Suppression in Mice. CNS Neurosci Ther. 2015 Aug;21(8):642-50

Zhang SH, Yu J, Lou GD, Tang YY, Wang RR, Hou WW, Chen Z. Widespread pain sensitization after partial infraorbital nerve transection in MRL/MPJ mice.Pain. 2016 Mar;157(3):740-9.

Wang Y, Liang J, Xu C, Wang Y, Kuang Y, Xu Z, Guo Y, Wang S, Gao F,Chen Z. Low-frequency stimulation in anterior nucleus of thalamus alleviates kainate-induced chronic epilepsy and modulates the hippocampal EEG rhythm. Exp Neurol. 2016 Feb;276:22-30.

Ma J, Zhang J, Hou WW, Wu XH, Liao RJ, Chen Y, Wang Z, Zhang XN, Zhang LS, Zhou YD, Chen Z,Hu WW. Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion.Sci Rep. 2015 Jul 15;5:12079.

Yue JX, Wang RR, Yu J, Tang YY, Hou WW, Lou GD, Zhang SH, Chen Z. Histamine Upregulates Nav1.8 Expression in Primary Afferent Neurons via H2 Receptors: Involvement in Neuropathic Pain.CNS Neurosci Ther. 2014 Jul 3.

Yu J, Fang Q, Lou GD, Shou WT, Yue JX, Tang YY, Hou WW, Xu TL, Ohtsu H, Zhang SH, Chen Z.Histamine modulation of acute nociception involves regulation of Nav1.8 in primary afferent neurons in mice. CNS Neurosci Ther.2013; 19(9):649-58.

Haijing Yan, Xiangnan Zhang, Weiwei Hu, Jing Ma, Weiwei Hou, Xingzhou Zhang, Xiaofen Wang, Jieqiong Gao, Yao Shen, Jianxin Lv, Hiroshi Ohtsu, Feng Han, Guanghui Wang, Zhong Chen. Histamine H3 Receptors Aggravate Cerebral Ischemic Injury by Histamine - independent Mechanisms. Nature Communications (2014) Feb 25;5:3344. doi: 10.1038/ncomms4334.

an-ying Fan, Zhe Shen, Ping He, Lei Jiang, Wei-wei Hou, Yao Shen, Xiangnan Zhang, Wei-wei Hu, Zhong Chen.A novel neuroprotective strategy for ischemic stroke: transient mild acidosis treatment by CO2 inhalation at reperfusion. J Cereb Blood Flow Metab ,2014 Feb;34(2):275-83

Wei-wei Hu, Zhe Wang, Shan-shan Zhang, Lei Jiang, Jing Zhang, Xiangnan Zhang, Qun-fang Lei, Hyun-Joo Park, Wen-jun Fang, Zhong Chen. Morphology and functions of astrocytes cultured on water-repellent fractal tripalmitin surfaces. Biomaterials. 2014 Aug;35(26):7386-97. 

Xiaoying Ying, Yi Wang, Jiao Liang, Jiaxing Yue, Cenglin Xu, Lina Lu, Zhenghao, Jianqing Gao, Yongzhong Du, Zhong Chen. Angiopep-conjugated electro-responsive hydrogel nanoparticles: therapeutic potential for epilepsy. Angew Chem Int Ed Engl. 2014 Nov 10; 53(46):12436-40

Xiangnan Zhang, Yang Yuan, Lei Jiang, Jingying Zhang, Jieqiong Gao, Zhe Shen, Yanrong Zheng, Tian Deng, Haijing Yan, Wenlu Li, Wei-Wei Hou, Jianxin Lu, Yao Shen, Haibing Dai, Wei-Wei Hu, Zhuohua Zhang and Zhong Chen: Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. (2014) Oct 1;10(10):1801-13

Wang Y, Xu Z, Cheng H, Guo Y, Xu C, Wang S, Zhang J, Ding M, Chen Z.Low-frequency stimulation inhibits epileptogenesis by modulating the early network of the limbic system as evaluated in amygdala kindling model. Brain Struct Funct. 2013 Jun 11.

Fang Q, Hu WW, Wang XF, Yang Y, Lou GD, Jin MM, Yan HJ, Zeng WZ, Shen Y, Zhang SH, Xu TL, Chen Z*.Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury.Neuropharmacology. 2013 Jun 18. 

 Zhang X, Yan H, Yuan Y, Gao J, Shen Z, Cheng Y, Shen Y, Wang RR, Wang X, Hu WW, Wang G, Chen Z.Cerebral ischemia-reperfusion-induced autophag protects against neuronal injury by mitochondrial clearance..Autophagy. 2013 Jun 12;9(9). 

Hu WW, Onuma T, Birukawa N, Abe M, Ito E, Chen Z, Urano A. Change of morphology and cytoskeletal protein gene expression during dibutyryl cAMP-induced differentiation in C6 glioma cells. Cell Mol Neurobiol. 2008;28(4):519-528.

Gong YX, Wang HJ, Zhu YP, Zhang WP, Dai HB, Zhang SH, Wei EQ, Chen Z. (2007) Carnosine ameliorates morphine-induced conditioned place preference in rats. Neurosci Lett. 422(1):34-8.

Hu WW, Yan H, Birukawa, Abe M, Ito E, Tsujii K, Chen Z, Urano A. Morphology of C6 Glioma Cells on a Water-Repellent Fractal Alkyl Ketene Dimer Surface. Current Nanoscience. 2008; 4(3): 224-231.

Hu W, Fan Y, Shen Y, Yang Y, Dai H, Fu Q, Chen Z. Mast cell-derived mediators protect against oxygen–glucose deprivation-induced injury in PC12 cells and neurons. Neurosci Lett, 2007;423:35-40.

Zhang SH, Sun QX, Seltzer Z, Cao DY, Wang HS, Chen Z, Zhao Y. Paracrine-like excitation of low-threshold mechanoceptive C-fibers innervating rat hairy skin is mediated by substance P via NK-1 receptors. Brain Res Bull. 2008;31;75(1):138-145. 

Li KX, Lu YM, Xu ZH, Zhang J, Zhu JM, Zhang JM, Cao SX, Chen XJ, Chen Z, Luo JH, Duan S, Li XM. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2011 Dec 11;15(2):267-73.

Jin MM, Chen Z. Role of gap junctions in epilepsy. Neurosci Bull. 2011;27(6):389-406.

Hu WW, Yang Y, Wang Z, Shen Z, Zhang XN, Wang GH, Chen Z. H1-antihistamines induce vacuolation in astrocytes through macroautophagy. Toxicol Appl Pharmacol. 2012;260 (2):115-123.

Shi WZ, Zhao CZ, Zhao B, Zheng XL, Fang SH, Lu YB, Zhang WP, Chen Z, Wei EQ. Aquaporin-4 deficiency attenuates acute lesions but aggravates delayed lesions and microgliosis after cryoinjury to mouse brain. Neurosci Bull. 2012;28(1):61-68.

He G, Hu J, Li T, Ma X, Meng J, Jia M, Lu J, Ohtsu H, Chen Z, Luo X. The arrhythmogenic effect of sympathetic histamine in mouse hearts subjected to acute ischemia. Mol Med. 2012;18(1):1-9.

Fan YY, Zhang XN, He P, Shen Z, Shen Y, Wang XF, Hu WW, Chen Z.Transient lack of glucose but not O₂ is involved in ischemic postconditioning-induced neuroprotection. CNS Neurosci Ther. （in Press）

Yu J, Lou GD, Yue JX, Tang YY, Hou WW, Shou WT, Ohtsu H, Zhang SH, Chen Z. Effects of histamine on spontaneous neuropathic pain induced by peripheral axotomy. Neurosci Bull.

Zhang CH, Fan YY, Wang XF, Xiong JY, Tang YY, Gao JQ, Shen Z, Song XH, Zhang JY, Shen Y, Li Q, Zhang X, Chen Z. Acidic preconditioning protects against ischemia-induced brain injury. Neurosci Lett. 2012 Aug 8;523(1):3-8.

Wang RR, Zhang XN, Zhang JX, Fan YY, Shen Y, Hu WW, Chen Z. Oxygen-glucose deprivation induced glial scar-like change in astrocytes. PLoS One. 2012;7(5):e37574.

Hu WW, Chen Z. Role of histamine and its receptors in cerebral ischemia. ACS Chem Neurosci. 2012;3 (4):238-247.

Ma J, Xiong JY, Hou WW, Yan HJ, Sun Y, Huang SW, Jin L, Wang Y, Hu WW, Chen Z. Protective effect of carnosine on subcortical ischemic vascular dementia in mice. CNS Neurosci Ther. 2012 ,18(9):745-753.

Xu ZH, Wang Y, Jin MM, Yue JX, Xu CL, Ying XY, Wu DC, Zhang SH, Chen Z. Polarity-dependent effect of low-frequency stimulation on amygdaloid kindling in rats. Brain Stimul. 2012,May 16

Zhong K, Wu DC, Jin MM, Xu ZH, Wang Y, Hou WW, Li XM, Zhang SH, Chen Z. Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats. Neurobiol Dis. 2012;48(1):20-26.

Hu WW, Fang Q, Xu ZH, Yan HJ, He P, Zhong K, Fan YY, Yang Y, Zhang XN, Zhang CY, Ohtsu H, Xu TL, Chen Z. Chronic H1-Antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase. CNS Neurosci Ther. 2012;18(8):683-690.

Fang Q, Chen Z. Increased asynchronous GABA release causes more inhibition in human epileptic brain? Acta Pharmacol Sin. 2012 Jul;33(7):859-860.

Liu L, Zhang S, Zhu Y, Fu Q, Zhu Y, Gong Y, Ohtsu H, Luo J, Wei E, Chen Z. (2007) Improved learning and memory of contextual fear conditioning and hippocampal CA1 long-term potentiation in histidine decarboxylase knock-out mice. Hippocampus,17(8):634-41.

Wang S, Ding MP, Wu DC, Zhan JB, Chen Z(2007).  ω-conotoxin MVIIA inhibits amygdaloid kindled seizures in Sprague-Dawley rats. Neurosci Lett, 2007,14;413(2):163-7.

Zhu Y, Zhuge Z, Wu D, Wang S, Liu L, Ohtsu H, Chen Z.(2007) Carnosine inhibits pentylenetetrazol-induced seizures by histaminergic mechanisms in histidine decarboxylase knock-out mice. Neurosci Lett,2007,416:211-6.

Dai HB, Fu QL, Shen Y, Hu WW, Zhang Z, Timmerman H, Leurs R, Chen Z.  (2007) The H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. Eur J Pharmacol, 2007,563(1-3):117-23.

Zhu-Ge ZB, Zhu YY, Wu DC, Wang S, Liu L, Hu W, Chen Z.(2007) Unilateral low-frequency stimulation of central piriform cortex inhibits amygdaloid-kindled seizures in Sprague-Dawley rats. Neuroscience, 2007,146(3):901-6.

Shen Y, Fan Y, Dai H, Fu Q, Hu W, Chen Z*.(2007) Neuroprotective effect of carnosine on necrotic cell death in PC12 cells. Neurosci Lett, 2007,414:145-9.

Jin CL, Zhuge ZB, Wu DC, Zhu YY, Wang S, Luo JH, Chen Z. (2007) Lesion of the tuberomammillary nucleus E2-region attenuates postictal seizure protection in rats. Epilepsy Res, 2007,73(3):250-8.

Shen Y, Hu WW, Fan YY, Dai HB, Fu QL, Wei EQ, Luo JH, Chen Z.(2007) Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors. Biochem Pharmacol, 2007,73(5):709-17.

Wang K, Shen HH, Huang HQ, Chen JC, Chen Z.(2008) Acetamide-45 inhibited hyperresponsiveness and airway inflammation in mice partly depending on phosphodiesterase activity suppression. Acta Pharmacol Sin, 2008,29(10):1195-201.

Wang S, Wu DC, Ding MP, Li Q, Zhu-Ge ZB, Zhang SH, Chen Z.(2008) Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague-Dawley rats. Neurobiol Dis, 2008,29(1):52-8.

 Fu Q, Dai H, Hu W, Fan Y, Shen Y, Zhang W, Chen Z. (2008) Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells. Cell Mol Neurobiol, 2008,28(2):307-16.

Wu DC, Xu ZH, Wang S, Fang Q, Hu DQ, Li Q, Sun HL, Zhang SH, Chen Z. (2008) Time-dependent effect of low-frequency stimulation on amygdaloid-kindling seizures in rats. Neurobiol Dis, 2008,31(1):74-9.  

Wu DC, Zhu-Ge ZB, Yu CY, Fang Q, Wang S, Jin CL, Zhang SH, Chen Z.(2008) Low-frequency stimulation of the tuberomammillary nucleus facilitates electrical amygdaloid-kindling acquisition in Sprague-Dawley rats. Neurobiol Dis, 2008,32(1):151-6 .

Gong N, Li Y, Cai GQ, Niu RF, Fang Q, Wu K, Chen Z, Lin LN, Xu L, Fei J, Xu TL . (2009) GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation. J Neurosci, 2009,29(50):15836-45.

Zhang SH, Sun HL, Fang Q, Zhong K, Wu DC, Wang S, Chen Z. (2009) Low-frequency stimulation of the hippocampal CA3 subfield is anti-epileptogenic and anti-ictogenic in rat amygdaloid kindling model of epilepsy. Neurosci Lett, 2009,455(1):51-5.

Stöckigt J, Chen Z, Ruppert M. (2010) Enzymatic and chemo-enzymatic approaches towards natural and non-natural alkaloids: indoles, isoquinolines, and others. Top Curr Chem, 2010,297:67-103.

Sun HL, Zhang SH, Zhong K, Xu ZH, Zhu W, Fang Q, Wu DC, Hu WW, Xiao B, Chen Z.(2010) Mode-dependent effect of low-frequency stimulation targeting the hippocampal CA3 subfield on amygdala-kindled seizures in rats. Epilepsy Res, 2010,90(1-2):83-90.

Xu ZH, Wu DC, Fang Q, Zhong K, Wang S, Sun HL, Zhang SH, Chen Z.(2010) Therapeutic time window of low frequency stimulation at entorhinal cortex for amygdaloid-kindling seizures in rats. Epilepsia, 2010,51(9):1861-1869.

Shen Y,  He P,  Fan YY, Zhang  JX,  Yan HJ ,  Hu WW,  Ohtsu H,  Chen Z.(2010) Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knock-out mice through reducing glutamate excitotoxicity. Free Radic Biol Med, 2010,48(5):727-35.

Fan YY, Hu WW, Dai HB, Zhang JX, Zhang LY, He P, Shen Y, Ohtsu H, Wei EQ, Chen Z.  (2011) Activation of the Central Histaminergic System is Involved in Hypoxia-Induced Stroke Tolerance in Adult Mice. J Cerebr Blood F Met, 2011,31(1):305-14.

Yan M, Dai H, Ding T, Dai A, Zhang F, Yu L, Chen G, Chen Z. (2011) Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells. Neurochem Int,2011,58(5):549-57.