**Speaker:  Guanghui Liu, PhD

**Time: Jan 17, 2013, 2:30 pm

**Place: Research Building, Room B502, School of Medicine

**Speaker Brief Introduction:

Guanghui Liu, PhD

Professor, Institute of Biophysics, Chinese Academy of Sciences

Education and Research Experience

1997-2002，B.S., Peking University Health Science Center

2002-2007，Ph.D., Institute of Biophysics, Chinese Academy of Sciences

2007-2009，Research associate, Dept. of Cell and Molecular Biology, The Scripps Research Institute

2009-2011，Research associate, Gene expression laboratory, The Salk Institute for Biological Studies

2010-2011，CIRM scholar, California Institute of Regenerative Medicine (CIRM)

2011-，Glenn fellow, Glenn Aging Foundation

2011-，Professor, Institute of Biophysics, Chinese Academy of Sciences

2012，Thousand Young Talents program of China

Research Interests

1. Modeling human diseases with pluripotent stem cells (PSCs)

2. Editing human genome in hPSCs

3. Mechanism of human aging and longevity

4. Nuclear architecture, chromatin organization, and human diseases

Representative publications

(1equal contribution; *Corresponding author)

1.Liu GH¹*, Qu J¹, Suzuki K¹, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Ren B, Wagner U, Kim A, Li Y, Goebl A, Kim J, Soligalla R, Dubova I, Thompson J, Yates J III, Esteban C, Sancho-Martinez I, Belmonte JC*. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.Nature. 2012; 491(7425):603-7.

2. Pan H1, Cai N1, Li M, Liu GH*, Izpisua Belmonte JC*. Autophagic control of cell stemness. EMBO Mol. Med. 2013. In press

3. Liu GH¹*, Ding Z¹, Izpisua Belmonte JC*. iPSC technology to study human aging and aging-related disorders.Curr Opin Cell Biol. 2012; Dec;24(6):765-74

4. Li M1, Liu GH¹, Belmonte JC.Navigating the epigenetic landscape of pluripotent stem cells.Nat Rev Mol Cell Biol.2012; 13(8):524-35.

5. Liu GH¹, Suzuki K¹, Qu J¹, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring J,Laurent L, and Belmonte JC. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011; 8(6):688-94

6.Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, III JY, Belmonte JC. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011; 14;472: 221-5